Alzheimer’s patients have significantly reduced levels of cholesterol and fats in the brain

This study was published in Alzheimer Disease and Associated Disorders 1998 Sep;12(3):198-203

Study title and authors:
Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.

Mulder M, Ravid R, Swaab DF, de Kloet ER, Haasdijk ED, Julk J, van der Boom JJ, Havekes LM.
Gaubius Laboratory, TNO-PG, Leiden, The Netherlands.

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/9772023

The study compared levels of cholesterol and fats in cerebrospinal fluid (cerebrospinal fluid is found in the brain and spinal canal) in Alzheimers patients and subjects without Alzheimers. The study assessed the brain tissue at postmortem in 30 Alzheimers cases and 31 age-matched control patients.

The study found:
(a) Cholesterol levels in the cerebrospinal fluid of patients without alzheimer's was 55% higher than in patients with Alzheimer's.
(b) Fatty acid levels (fat molecules) in the cerebrospinal fluid of patients without alzheimer's was 522% higher than in patients with Alzheimer's.
(c) Phospholipid levels (phospholipids contain two molecules of fat and are a major component of cell membranes) in the cerebrospinal fluid of patients without alzheimer's was 1650% higher than in patients with Alzheimer's.

The results of the study show that Alzheimer’s patients have significantly reduced levels of cholesterol and fats in the cerebrospinal fluid.

Amazon Review of my book "Cholesterol and Saturated Fat Prevent Heart Disease - Evidence from 101 Scientific Papers"

3 of 3 people found the following review helpful

5.0 out of 5 stars Easy to understand, packed full of amazing information!, November 3, 2012

By 

Lisa Nicole Lawrence "Lisa Lawrence" (Antigonish, nova scotia Canada) - See all my reviews
(REAL NAME)   

Amazon Verified Purchase(What's this?)

This review is from: Cholesterol and Saturated Fat Prevent Heart Disease - Evidence from 101 Scientific Papers (Paperback)

When I first saw this book I assumed I would not be able to understand "scientific papers" as I have no scientific knowledge (aside from gr. 12 biology, 25 yrs ago), but the studies were explained so well and strung together so well, they were easy and enjoyable to read.

I was blown away by the evidence contrary to the typical eat-low-fat-for-your-heart medical advice, I especially enjoyed Chapter 5, "Comments by Eminent Professors and Doctors" (leading experts on the subject of cardiovascular disease), the glossary, and Appendix 3 which provided quick summaries of one or two lines of each of the studies.

After my father who was slender and had low cholesterol, died of a heart attack, my vegetarian/whole foods mom got a brain aneurysm and my young, fit husband developed a heart condition, I began a research quest and started to question all I knew for certain about diet and health. This led to my adoption of a low carbohydrate, real food lifestyle which has greatly improved my health. Reading this book provided me with the evidence behind my intuitive and physical experience of ridding myself of the fear of eating natural fat. I will be passing it out to each of my friends who asks me why I am not afraid of clogging my arteries. It was reassuring and it is a great accessible resource. (I will be buying a few more copies to give to my doctors as well).

Lisa

Amazon review accessed here http://www.amazon.com/Cholesterol-Saturated-Prevent-Disease-ebook/product-reviews/B008O53WDK/ref=cm_cr_pr_hist_5?ie=UTF8&filterBy=addFiveStar&showViewpoints=0

Eating liver is associated with a reduction in stomach cancer

This study was published in the International Journal of Cancer 2002 Jun 10;99(5):727-31

 

Study title and authors:

A case-control study of stomach cancer in Mumbai, India.

Rao DN, Ganesh B, Dinshaw KA, Mohandas KM.

Division of Epidemiology and Biostatistics, Tata Memorial Hospital, Parel, Mumbai, India. dnrao@hotmail.com

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12115507

The  purpose of the study was to identify the association of various factors with stomach cancer. The study participants were aged between 30-75 and included 170 stomach cancer cases and 2,184 controls.

The study found:
(a) Beef consumption was associated with a small reduction in stomach cancer risk.
(b) Those who consumed liver at least once per week had a 30% reduced risk of stomach cancer compared to those who never had liver or only once every two weeks.

The data from the study shows that liver consumption is associated with a reduction in stomach cancer.

Statin use is associated with a rise of fasting blood glucose levels in patients with and without diabetes

This study was published in the Journal of Investigative Medicine 2009 Mar;57(3):495-9

 

Study title and authors:

Effect of statins on fasting plasma glucose in diabetic and nondiabetic patients.

Sukhija R, Prayaga S, Marashdeh M, Bursac Z, Kakar P, Bansal D, Sachdeva R, Kesan SH, Mehta JL.

Division of Cardiovascular Medicine, Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/19188844

When blood sugar levels remain high for several hours, dehydration and more serious complications can develop. Even slightly raised blood sugar levels (a fasting blood sugar over 109 mg/dL or 6.05 mmol/L) when unrecognized - can damage multiple tissues in the brain, kidneys, and arteries.

This study investigated the effects of statins on fasting blood sugar levels. The study included diabetics and non-diabetics, statin users and non-users, and analysed the change in fasting blood sugar levels in 345,417 patients, average age 61, over a two year period.

The study found:
(a) Fasting blood sugar levels increased by an extra 29% in non-diabetic statin users compared to non-diabetic non-users.
(b) Fasting blood sugar levels increased by an extra 18% in diabetic statin users compared to diabetic non-users.

The study reveals that statin use is associated with a rise of fasting blood glucose levels in patients with and without diabetes.

Higher saturated fat and cholesterol consumption is associated with a lower risk of dementia

This study was published in Neurology 2002 Dec 24;59(12):1915-21

 

Study title and authors:

Diet and risk of dementia: Does fat matter?: The Rotterdam Study.

Engelhart MJ, Geerlings MI, Ruitenberg A, Van Swieten JC, Hofman A, Witteman JC, Breteler MM.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12499483

The objective of the study was to examine whether intake of fats are associated with the risk of dementia. The dietary habits of 5,395 subjects with normal cognition were assessed over a six year period.

The study found:
(a) Higher fat consumption was associated with a 7% reduction in dementia.
(b) Higher saturated fat consumption was associated with a 9% reduction in dementia.
(c) Higher cholesterol consumption was associated with a 7% reduction in dementia.
(d) Higher polyunsaturated fat consumption was associated with a 5% increase in dementia.

The data from the study reveals that higher saturated fat and cholesterol consumption is associated with a lower risk of dementia.

Statins increase the risk of adverse medical events by 39%

This study was published in Clinical Therapeutics 2006 Jan;28(1):26-35

Study title and authors:
Statin-related adverse events: a meta-analysis.

Silva MA, Swanson AC, Gandhi PJ, Tataronis GR.
Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts 01608, USA. msilva@wor.mcphs.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/16490577

This study is a meta-analysis of statin randomized clinical trials that compare the number of adverse effects caused by statin treatment or placebo. The search through medical databases found 18 trials including 71,108 persons, and 301,374 person-years of follow-up. There were 36,062 persons receiving a statin and 35,046 receiving a placebo. (An adverse event is any untoward medical occurrence in a patient administered a pharmaceutical product).

The study found that statin therapy increased the risk of adverse events by 39%.

Artificial sweetener users are significantly more likely than nonusers to gain weight

This study was published in Preventive Medicine 1986 Mar;15(2):195-202

 

Study title and authors:

Artificial sweetener use and one-year weight change among women.

Stellman SD, Garfinkel L.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/3714671

This study investigated the effects of artificial sweeteners on weight change. The study included 78,694 women, aged 50-69, who were followed for one year.

The study found that artificial sweetener users were significantly more likely than nonusers to gain weight, regardless of their initial weight.