Low cholesterol levels may lead to permanent psychomotor, cognitive, motorsystem damage, hypoadrenalism and infertility in both males and females

This study was published in the Journal of Ayub Medical College Abbottabad 2010 Jul-Sep;22(3):225-7

Study title and authors:
Hypocholesterolemia secondary to atrovastatin therapy.

Ali S, Khan SA, Iram S.
Department of Medicine, NIMS Medical College and Teaching Hospital, Abbottabad, Pakistan. drshafqutali@hotmail.com

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22338462

This paper describes the case of a 40 years old male who was started on Atorvastatin after his angioplasty (angioplasty is the technique of mechanically widening narrowed or obstructed arteries) following a heart attack.

(i) Six weeks after the start of statin therapy the patient developed symptoms of phobias, nightmares, insomnia, forgetfulness, body aches, muscle cramps, cognitive, sexual and psychomotor disturbances.
(ii) On investigation he was found to have low cholesterol levels.
(iii) Atorvastatin was stopped and over a five month period the patients symptoms resolved as his cholesterol levels became normal.

The study concluded that if patients have low cholesterol levels it can lead to permanent psychomotor, cognitive, motorsystem damage, hypoadrenalism, infertility in both males and females along with permanent affects of fat soluble vitamins deficiencies.

Higher fat consumption is associated with lower rates of colon cancer

This study was published in the International Journal of Cancer 2010 Aug 15;127(4):942-51

 

Study title and authors:

Dietary fatty acids, luminal modifiers, and risk of colorectal cancer.

Kato I, Majumdar AP, Land SJ, Barnholtz-Sloan JS, Severson RK.

Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/19998336

This study assessed the association between fat intake and colorectal cancer. The study included 1,163 subjects with colon cancer and 1,501 healthy control subjects.

The study found:
(a) Those who consumed the most fat had a 16% decreased risk of colon cancer compared to those who consumed the least fat.
(b) Those who consumed the most saturated fat had a 5% decreased risk of colon cancer compared to those who consumed the least saturated fat.

The data from the study shows that a higher consumption of fat is associated with lower rates of colon cancer.

Low intake of dietary fat is associated with higher rates of hypothalamic amenorrhea

This study was published in the Journal of the Society for Gynecologic Investigation 1994 Jan-Mar;1(1):84-8

Study title and authors:
Hypothalamic amenorrhea and hidden nutritional insults.

Warren MP, Holderness CC, Lesobre V, Tzen R, Vossoughian F, Brooks-Gunn J.
Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital, New York, New York, USA.

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/9419753

The study examined the association between nutritional intake and hypothalamic amenorrhea. The study included 18 amenorrheic women who were compared to 36 normal women.

The study found:
(a) The amenorrheic women consumed 78% more fibre than the normal women.
(b) The amenorrheic women consumed 24% less fat than the normal women.

The data from the study reveals that amenorrheic women consume more fibre and less fat than normal women.

Low levels of low density Lipoprotein (LDL) cholesterol are associated with higher death rates in patients with acute heart failure

This study was published in Congestive Heart Failure 2012 Oct 16

 

Study title and authors:

Low-Density Lipoprotein Levels in Patients With Acute Heart Failure.

Kahn MR, Kosmas CE, Wagman G, Serrao GW, Fallahi A, Grady KM, Vittorio TJ.

Department of Internal Medicine, Mount Sinai Medical Center, New York, NY

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/23066917

This study investigated the association of cholesterol levels with death rates in patients hospitalised with heart failure. The study included 2,428 patients who were followed for 2.9 years.

The study found that those with low levels of low density liporotein (LDL) cholesterol, less than 71 mg/dL (1.8 mmol/L), had a 68% increased death rate compared to those with high levels of low density liporotein (LDL) cholesterol, more than 130 mg/dL (3.3 mmol/L).

Low dietary fat intake associated with hypothalamic amenorrhea

This study was published in the Journal of Clinical Endocrinology and Metabolism 1998 Jul;83(7):2309-12

 

Study title and authors:

Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake.

Miller KK, Parulekar MS, Schoenfeld E, Anderson E, Hubbard J, Klibanski A, Grinspoon SK.

Neuroendocrine Unit, Massachusetts General Hospital, Boston 02114, USA.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/9661600

This study investigated factors that may lead to hypothalamic amenorrhea (hypothalamic amenorrhea is a condition in which menstruation stops for several months due to a problem involving the hypothalamus). The study included 21 women with hypothalamic amenorrhea who were compared with 30 age-, weight-, and body fat-matched women with normal menstruation.

Regarding fat intake, the study found that women with hypothalamic amenorrhea consumed 48% less fat than women with normal menstruation.

High cholesterol levels predict higher survival rates in patients with acute coronary syndromes

This study was published in Clinical Cardiology 2009 Sep;32(9):E22-8

 

Study title and authors:

Hypercholesterolemia paradox in relation to mortality in acute coronary syndrome.

Wang TY, Newby LK, Chen AY, Mulgund J, Roe MT, Sonel AF, Bhatt DL, DeLong ER, Ohman EM, Gibler WB, Peterson ED.

Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA. wang0085@mc.duke.edu

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/19645040

This study investigated the association of cholesterol levels with in-hospital death rates in patients with acute coronary syndromes. (Acute coronary syndromes is an umbrella term for situations where the blood supplied to the heart muscle is suddenly blocked). The study included 84,429 patients with acute coronary syndromes and examined data regarding patients with (i) a history of existing high cholesterol and (ii) newly in-hospital diagnosed high cholesterol.

Patients were defined as the following:
(i) A history of existing high cholesterol was defined as more than 200 mg/dL (5.2 mmol/L) or treatment with cholesterol lowering drugs.
(ii) Newly in-hospital diagnosed high cholesterol was defined as low density lipoprotein (LDL) cholesterol levels more than 100 mg/dL (2.6 mmol/L).

The study found:
(a) Patients with a history of existing high cholesterol had a 29% reduced death death rate compared to patients with a history of existing low cholesterol.
(b) Patients with no history of existing high cholesterol, but with newly in-hospital diagnosed high LDL cholesterol had a 14% reduced death death rate compared to patients with normal LDL cholesterol.

The data from the study reveals that high cholesterol levels predict higher survival rates in patients with acute coronary syndromes.

Statins cause definite damage to the peripheral nerves

This study was published in Neuro Endocrinology Letters 2011;32(5):688-90

Study title and authors:
Treatment with statins and peripheral neuropathy: results of 36-months a prospective clinical and neurophysiological follow-up.

Otruba P, Kanovsky P, Hlustik P.
Department of Neurology, Palacky University Medical School, University Hospital, Olomouc, Czech Republic. pavel.otruba@fnol.cz

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22167150

 

This study investigated the effects of statin treatment on lower-limb peripheral nerves. The study included 42 patients on statin therapy who were followed for three years.

The study found that long-term treatment with statins caused definite damage to peripheral nerves when the treatment lasts longer than two years.